Cell Signaling Zip8/Slc39a8 (E2l8e) Rabbit mAb

Name: Cell Signaling Zip8/Slc39a8 (E2l8e) Rabbit mAb
SKU: CSIG-35993S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Zip8/Slc39a8 (E2l8e) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-35993S

MFG.PART: 35993S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	65, 130
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	ZIP8/SLC39A8 (E2L8E) Rabbit mAb recognizes endogenous levels of total ZIP8/SLC39A8 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human ZIP8/SLC39A8 protein.
Background	Zinc transporter zinc-and iron-related protein 8 (ZIP8) is encoded by the SLC39A8 gene and is a member of the solute carrier gene (SLC) superfamily (1). As a membrane protein, ZIP8 functions to transport manganese, cadmium, and zinc across the plasma membrane (2). Metal ions are essential elements that are required cofactors for proteins, including enzymes and transcription factors. Maintenance of proper metal ion homeostasis is required for normal mammalian tissue development and function. Mice lacking SLC39A8 reveal a critical role of ZIP8 in organogenesis in multiple tissues, including the brain and kidney, during development (3,4). Mutations in SLC39A8 are linked to autosomal-recessive forms of intellectual disability, suggesting that altered ZIP8-dependent metal ion regulation may contribute to human neuronal developmental diseases (5).

Specifications