Cell Signaling Cd70 (E3q1a) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Cd70 (E3q1a) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-35969SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Cd70 (E3q1a) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-35969SF

MFG.PART: 35969SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	27, 54, 81
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free. For standard formulation of this product see product #69209.
Specificity/Sensitivity	CD70 (E3Q1A) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total CD70 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human CD70 protein.
Background	CD70 is a type II transmembrane glycoprotein and a member of the tumor necrosis factor ligand superfamily (TNFSF), also known as CD27L and TNFSF7. It is normally expressed on medullary thymic epithelial cells. Its expression is induced on activated lymphoid cells (B cells, T cells, and NK cells) and dendritic cells. CD70 is a ligand for CD27, a co-stimulatory receptor that plays an important role in T cell activation and proliferation (1,2). CD70 overexpression has been reported in various tumors such as renal cell carcinoma, glioblastoma, and non-small cell lung carcinoma and it’s being actively pursued as a therapeutic target (3-6).

Specifications