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Cell Signaling Hsd17b13 (E5k7q) Rabbit mAb
List Price
$374.71
Your Price
$374.71
Cell Signaling Hsd17b13 (E5k7q) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-35371S
MFG.PART:
35371S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 30 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:100} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | HSD17B13 (E5K7Q) Rabbit mAb recognizes endogenous levels of total HSD17B13 protein. |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser103 of human HSD17B13 protein. |
| Background | HSD17B13, also known as hydroxysteroid 17-beta dehydrogenase 13, is a liver-enriched, hepatocyte-specific, lipid droplet-associated protein involved in the metabolism of steroid hormones (1). HSD17B13 has been linked to the development of non-alcoholic fatty liver disease (NAFLD), a condition characterized by the accumulation of fat in the liver that can lead to liver damage and inflammation (2). Hepatic expression of HSD17B13 is significantly upregulated in NAFLD patients relative to healthy individuals, with expression levels correlating with disease severity (3,4). Moreover, several loss-of-function variants in HSD17B13 are associated with a reduced risk of chronic liver disease and decreased disease severity of NAFLD. (5,6). These findings suggest that HSD17B13 may be a potential therapeutic target for the treatment of liver fibrosis and NAFLD. |
| SKU | CSIG-35371S |
|---|---|
| Featured | No |
| Supplier Part Number | 35371S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |