Cell Signaling Rala Antibody

Name: Cell Signaling Rala Antibody
SKU: CSIG-3526S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Rala Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-3526S

MFG.PART: 3526S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	25
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	RalA Antibody detects endogenous levels of total human RalA protein.
Species Reactivity	Human, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala142 of human RalA. Antibodies are purified by peptide affinity chromatography.
Background	RalA and RalB are members of the Ras family of small GTPases and are highly homologous in protein sequence. The functions of RalA and RalB are distinct yet overlapping. By binding to various effector proteins, RalA and RalB serve as important GTP sensors for exocytosis and membrane trafficking (1-3). RalA is required for Ras-related tumorigenesis (4) and RalB is important for tumor survival (5). In addition to tumor formation, Ral proteins also play a role in cancer cell migration and metastatic tumor invasion (6,7).

Specifications