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Cell Signaling Nyap1 (E6d4s) Rabbit mAb
List Price
$342.39
Your Price
$342.39
Cell Signaling Nyap1 (E6d4s) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-35227S
MFG.PART:
35227S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H M R |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 105 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | NYAP1 (E6D4S) Rabbit mAb recognizes endogenous levels of total NYAP1 protein. |
| Species Reactivity | Human, Mouse, Rat |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser369 of human NYAP1 protein. |
| Background | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 (NYAP1) is a member of the Nyap family of phosphoproteins, including NYAP1, NYAP2, and Myosin16/NYAP3. Upon stimulation by contactin5, NYAPs are phosphorylated by Fyn. Once phosphorylated, NYAP1, as well as other members of this family, interacts with PI3K p85 and active PI3K, Akt, and Rac1. The interaction of NYAP1 with WAVE complex mediates remodeling of the actin cytoskeleton after activation by PI3K-produced PIP3 and Rac1 (1). The phosphorylation of NYAP1 directly contributes to normal neuronal migration and morphogenesis of neurons, acting downstream of Fyn, which is a non-receptor protein-tyrosine kinase that is a member of the Src kinase family (2). The overexpression of NYAP1 promotes neurite branching and elongation at early neuronal migration compared to the NYAP1-KO model. The lack of NYAP1 induces thinner leading neurites affecting the multibipolar morphology of neurons (2). |
| SKU | CSIG-35227S |
|---|---|
| Featured | No |
| Supplier Part Number | 35227S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |