Cell Signaling Steep Antibody

Name: Cell Signaling Steep Antibody
SKU: CSIG-35136S
Price: 359.56 USD

List Price $359.56 Your Price $359.56

Cell Signaling Steep Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-35136S

MFG.PART: 35136S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	28
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	STEEP Antibody recognizes endogenous levels of total STEEP protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human STEEP protein. Antibodies are purified by peptide affinity chromatography.
Background	STING ER exit protein (STEEP) is a highly conserved, ubiquitously expressed protein, which has been shown to be a positive regulator of the cGAS-STING signaling pathway. Mechanistically, research studies have demonstrated that STEEP constitutively interacts with STING to coordinate STING ER-to-Golgi trafficking, which is an essential step to ensure productive STING-dependent signaling and gene expression in response to viral infection (1).

Specifications