Cell Signaling Beta-Catenin (L54e2) Mouse mAb (Bsa And Azide Free)

Name: Cell Signaling Beta-Catenin (L54e2) Mouse mAb (Bsa And Azide Free)
SKU: CSIG-34396SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Beta-Catenin (L54e2) Mouse mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-34396SF

MFG.PART: 34396SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	92
Source/Isotype	Mouse IgG1
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #2677
Specificity/Sensitivity	β-Catenin (L54E2) Mouse mAb (IF Preferred) (BSA and Azide Free) detects endogenous levels of total β-catenin protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of human β-catenin.
Background	β-catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8).

Specifications