Cell Signaling Id2 (D39e8) Rabbit mAb

Name: Cell Signaling Id2 (D39e8) Rabbit mAb
SKU: CSIG-3431S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Id2 (D39e8) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-3431S

MFG.PART: 3431S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	15
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Id2 (D39E8) Rabbit mAb detects endogenous levels of total Id2 protein.
Species Reactivity	Human, Mouse, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn97 of human Id2 protein.
Background	Inhibitor of DNA-binding-2 (Id2) is a member of the Id proteins which belong to the helix-loop-helix (HLH) protein family. The Id protein functions by binding to specific transcription factors and preventing their dimerization and DNA binding (1-3). Id2 interacts with a wide variety of transcription factors including E proteins (5), TCS (4), Pax (3) and the tumor suppressor Rb (1). Id2 has been shown to be important in regulating cellular differentiation, proliferation, development and tumorgenesis (6-8). In tumor cells, increased levels of Id2 functionally inactivate Rb, leading to cellular transformation and cancer (9,10). Id2 is therefore a promising therapeutic target for treatment of cancer (11).

Specifications