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Cell Signaling Slmap Antibody
List Price
$309.06
Your Price
$309.06
Cell Signaling Slmap Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-34161S
MFG.PART:
34161S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H M R Mk |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 90-95 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | SLMAP Antibody recognizes endogenous levels of total SLMAP protein. Based on antigen sequence, the antibody is predicted to detect isoforms 1-4 and isoform 6 of SLMAP. |
| Species Reactivity | Human, Mouse, Rat, Monkey |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp464 of human SLMAP protein. Antibodies are purified by peptide affinity chromatography. |
| Background | Sarcolemmal membrane-associated protein (SLMAP) is a tail-anchored membrane protein involved in the docking and membrane fusion process (1). It is also a component of a conserved striatin-interacting phosphatase and kinase complex (STRIPAK) which participates in a variety of cellular processes, including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis (2-4). There are several isoforms of SLMAP as a result of alternative splicing; shorter isoforms exhibit high expression in cardiac muscle, whereas the longer isoforms are expressed more ubiquitously, but at lower levels (5). As a cardiac membrane protein, SLMAP plays an important role in excitation-contraction coupling and the adrenergic response, and has been identified as a novel regulator of cardiac function (6-8). In support of that function, mutations in the SLMAP gene are associated with Brugada syndrome, a cardiac channelopathy (9). Deregulation of SLMAP expression has also been implicated in type 2 diabetes, and changes in SLMAP expression are linked to hyperglycemia and diabetes (10). Additionally, a novel SLMAP-ALK fusion has been identified in a patient with non-small cell lung cancer (11). |
| SKU | CSIG-34161S |
|---|---|
| Featured | No |
| Supplier Part Number | 34161S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |