Cell Signaling Lpp (8b3a11) Mouse mAb

Name: Cell Signaling Lpp (8b3a11) Mouse mAb
SKU: CSIG-3389S
Price: 339.36 USD

List Price $339.36 Your Price $339.36

Cell Signaling Lpp (8b3a11) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-3389S

MFG.PART: 3389S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M Hm Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	75
Source/Isotype	Mouse IgG1
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50, Immunohistochemistry (Paraffin): 1:100, Immunofluorescence (Immunocytochemistry): 1:100}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	LPP (8B3A11) Mouse mAb detects endogenous levels of total LPP protein.
Species Reactivity	Human, Mouse, Hamster, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a HIS-tagged recombinant fragment of human LPP.
Background	LIM-containing lipoma-preferred partner (LPP) belongs to the zyxin family, members of which include LIMD1, ajuba, trip6 and zyxin. Three LIM domains at the carboxy-terminus characterize this family of proteins. Zyxin family members associate with the actin cytoskeleton and are components of both the cell-cell junction adhesive complex and the integrin-mediated adhesive complex (1). They shuttle in and out of the nucleus where they may function in transcriptional activation (1).LPP binding partners at cell-cell contacts include the actin regulator α-actinin (2) and the human tumor suppressor scrib which regulates cell migration and polarity (3).

Specifications