Cell Signaling Cofilin (D59) Antibody

Name: Cell Signaling Cofilin (D59) Antibody
SKU: CSIG-3318S
Price: 353.50 USD

List Price $353.50 Your Price $353.50

Cell Signaling Cofilin (D59) Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-3318S

MFG.PART: 3318S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk B
Sensitivity	Endogenous
Molecular Weight (kDa)	19
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Cofilin (D59) Antibody detects endogenous levels of total cofilin protein.
Species Reactivity	Human, Mouse, Rat, Monkey, Bovine
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp59 of human cofilin. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Cofilin and actin-depolymerization factor (ADF) are members of a family of essential conserved small actin-binding proteins that play pivotal roles in cytokinesis, endocytosis, embryonic development, stress response, and tissue regeneration (1). In response to stimuli, cofilin promotes the regeneration of actin filaments by severing preexisting filaments (2). The severing activity of cofilin is inhibited by LIMK or TESK phosphorylation at Ser3 of cofilin (3-5). Phosphorylation at Ser3 also regulates cofilin translocation from the nucleus to the cytoplasm (6).

Specifications