Cell Signaling Phospho-Jak Family (Tyr1007/1008) (E9e4o) Rabbit mAb

Name: Cell Signaling Phospho-Jak Family (Tyr1007/1008) (E9e4o) Rabbit mAb
SKU: CSIG-32901S
Price: 405.01 USD

List Price $405.01 Your Price $405.01

Cell Signaling Phospho-Jak Family (Tyr1007/1008) (E9e4o) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-32901S

MFG.PART: 32901S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	115-135
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Phospho-Jak Family (Tyr1007/1008) (E9E4O) Rabbit mAb recognizes endogenous levels of Jak1 protein only when phosphorylated at Tyr1034 and/or Tyr1035, Jak2 protein only when phosphorylated at Tyr1007 and/or Tyr1008, Jak3 protein only when phosphorylated at Tyr980 and/or Tyr981, and Tyk2 protein only when phosphorylated at Tyr1054 and/or Tyr1055.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1007/Try1008 of human Jak2 protein.
Background	Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats (2), Shc (3), insulin receptor substrates (4), and focal adhesion kinase (FAK) (5), typically contain SH2 or other phospho-tyrosine-binding domains.

Specifications