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Cell Signaling Profilin-1 Antibody
List Price
$309.06
Your Price
$309.06
Cell Signaling Profilin-1 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-3237S
MFG.PART:
3237S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H M R B |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 15 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000, Immunofluorescence (Immunocytochemistry): 1:50, Flow Cytometry (Fixed/Permeabilized): 1:100} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | Profilin-1 Antibody detects endogenous levels of total profilin-1 protien. The antibody may cross-react with profilin-2. |
| Species Reactivity | Human, Mouse, Rat, Bovine |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to human profilin-1. Antibodies are purified using protein A and peptide affinity chromatography. |
| Background | The dynamic polymerization and depolymerization of actin filaments, a process governed by external and internal signaling events, is vital for cell motility (immune cell function, migration, invasion, metastasis, angiogenesis), cell division and adhesion. Among the many regulators of actin dynamics are profilins. Profilins are conserved actin binding proteins that affect the rate of actin polymerization by binding actin monomers and promoting the exchange of ADP for ATP (reviewed in 1). Profilins bind to proteins involved in the regulation of actin dynamics including palladin (2), dynamin-1 (3), VASP (4) and N-WASP (5). In mice, knockout of the ubiquitously expressed profilin-1 indicates that the protein is essential for embryonic development (6). Profilin-2 is primarily expressed in brain and functions in the regulation of neurite outgrowth (7), membrane trafficking and endocytosis (3). The recently cloned profilin-3 is expressed in kidney and testes (8). |
| SKU | CSIG-3237S |
|---|---|
| Featured | No |
| Supplier Part Number | 3237S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |