Cell Signaling Dvl2 Antibody

Name: Cell Signaling Dvl2 Antibody
SKU: CSIG-3216S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Dvl2 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-3216S

MFG.PART: 3216S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Hm Mk Mi
Sensitivity	Endogenous
Molecular Weight (kDa)	90 to 95
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:200}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Dvl2 Antibody detects endogenous levels of total Dvl2 protein. It does not cross-react with Dvl3.
Species Reactivity	Human, Mouse, Rat, Hamster, Monkey, Mink
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser638 of human Dvl2. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Dishevelled (Dsh) proteins are important intermediates of Wnt signaling pathways. Dsh inhibits glycogen synthase kinase-3β promoting β-catenin stabilization. Dsh proteins also participate in the planar cell polarity pathway by acting through JNK (1,2). There are three Dsh homologs, Dvl1, Dvl2 and Dvl3 in mammals. Upon treatment with Wnt proteins, Dvls become hyperphosphorylated (3) and accumulate in the nucleus (4). Dvl proteins also associate with actin fibers and cytoplasmic vesicular membranes (5) and mediate endocytosis of the Fzd receptor after Wnt protein stimulation (6). Overexpression of Dvl has been reported in certain cancers (7,8).

Specifications