Cell Signaling Nqo1 (A180) Mouse mAb

Name: Cell Signaling Nqo1 (A180) Mouse mAb
SKU: CSIG-3187S
Price: 339.36 USD

List Price $339.36 Your Price $339.36

Cell Signaling Nqo1 (A180) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-3187S

MFG.PART: 3187S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	29
Source/Isotype	Mouse IgG1
Application/Dilution	{Western Blotting: 1:1000, Immunohistochemistry (Paraffin): 1:50, Immunofluorescence (Immunocytochemistry): 1:400}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	NQO1 (A180) Mouse mAb detects endogenous levels of total NQO1 protein.
Species Reactivity	Human
Source/Purification	NQO1 (A180) Mouse mAb is produced by immunizing mice with purified recombinant human NQO1.
Background	NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes the two-electron reduction of quinones and their derivatives (1,2). This enzyme protects cells against redox cycling and oxidative stress (1,3). The expression of NQO1 is increased in liver, colon and breast tumors and non-small cell lung cancer (NSCLC) compared with the normal tissues (1,2). Moreover, expression levels are also elevated in developing tumors, suggesting a role for NQO1 in the prevention of tumor development (1). Studies on NQO1 knockout mice suggest that the lack of NQO1 enzymatic activity changes intracellular redox states resulting in a reduction in apoptosis, which in turn leads to myeloid hyperplasia of bone marrow (2).

Specifications