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Cell Signaling G3bp2 Antibody
List Price
$364.61
Your Price
$364.61
Cell Signaling G3bp2 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-31799S
MFG.PART:
31799S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H M R Mk |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 60, 70 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50, Immunofluorescence (Immunocytochemistry): 1:100 - 1:400} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | G3BP2 Antibody recognizes endogenous levels of total G3BP2 protein. |
| Species Reactivity | Human, Mouse, Rat, Monkey |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human G3BP2 protein. Antibodies are purified by peptide affinity chromatography. |
| Background | Stress granules (SGs) are cytoplasmic mRNA-protein condensates formed in response to cellular stressors, such as oxidative stress, ultraviolet radiation, and viral infection (1). The Ras-GTPase-activating protein-binding proteins (G3BPs), consisting of G3BP1 and G3BP2, are key nucleating factors essential for SG formation (2). As their name suggests, G3BPs were originally identified as proteins that interact with the SH3 domain of Ras GTPase-activating protein (RasGAP) (3). However, a recent study argues that G3BP1 may not be a genuine RasGAP-binding partner, suggesting that further studies are necessary to validate this particular function (4). Rather, G3BPs are well known to be involved in mRNA decay and inhibition of translation initiation (5,6). The SARS-CoV-2 virus has also been reported to target G3BPs via interaction between the viral N protein and the N-terminal domain of G3BP. This binding prevents G3BPs from interacting with other SG-associated proteins, therefore suppressing SG assembly and promoting viral replication (7). G3BP2 in particular has also been reported to play a role in the initiation of breast tumor formation, as well as affect the expression of PD-L1 in breast and glioblastoma cells under stress conditions (8,9). |
| SKU | CSIG-31799S |
|---|---|
| Featured | No |
| Supplier Part Number | 31799S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |