Cell Signaling Dimt1 Antibody

Name: Cell Signaling Dimt1 Antibody
SKU: CSIG-31358S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Dimt1 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-31358S

MFG.PART: 31358S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	35
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	DIMT1 Antibody recognizes endogenous levels of total DIMT1 protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val98 of human DIMT1 protein. Antibodies are purified by peptide affinity chromatography.
Background	Dimethyladenosine transferase 1 (DIMT1), also known as DIMT1L, is a methyltransferase responsible for the dimethylation of adenosines on the 18S rRNA subunit. Binding of DIMT1 to the pre-rRNA is required for proper processing of the 18S subunit (1). Independent of its catalytic activity, DIMT1 seems to function as a scaffold protein that is essential for the assembly of the 40S rRNA subunit (2). DIMT1 also has been shown to have higher expression in certain cancer types, including multiple myeloma and gastric cancer (3,4).

Specifications