Cell Signaling Ccl5/Rantes (R40) Antibody

Name: Cell Signaling Ccl5/Rantes (R40) Antibody
SKU: CSIG-2987S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Ccl5/Rantes (R40) Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-2987S

MFG.PART: 2987S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	10
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CCL5/RANTES (R40) Antibody detects endogenous levels of total human CCL5/RANTES protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg40 of human CCL5/RANTES. Antibodies were purified by protein A and peptide affinity chromatography.
Background	RANTES/CCL5 (regulated upon activation, T cell expressed and secreted) is a member of the "C-C" or β family of chemokines that induce inflammation and are associated with a number of inflammatory disorders (1,2). RANTES is produced and secreted mainly by CD8+ T cells, macrophages, and platelets, as well as epithelial cells, fibroblasts, and some solid tumors (2-7). RANTES acts as a chemoattractant and has other regulatory functions on a number of cell types, including monocytes, memory T cells, NK cells, eosinophils, basophils, dendritic cells, and mast cells (3, 7-9). Signaling by RANTES is mediated by several G protein-coupled receptors (GPCRs), including CCR1, CCR3, CCR4, and CCR5.

Specifications