Cell Signaling Cd48 (D7l8i) Xp Rabbit mAb

Name: Cell Signaling Cd48 (D7l8i) Xp Rabbit mAb
SKU: CSIG-29499T
Price: 156.55 USD

List Price $156.55 Your Price $156.55

Cell Signaling Cd48 (D7l8i) Xp Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-29499T

MFG.PART: 29499T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	20 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	45-50
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, IHC Leica Bond: 1:200, Immunohistochemistry (Paraffin): 1:400}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #90615.
Specificity/Sensitivity	CD48 (D7L8I) XP® Rabbit mAb recognizes endogenous levels of total CD48 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human CD48 protein.
Background	CD48 is a glycosylphosphatidylinositol (GPI) -anchored membrane protein of the signaling lymphocyte activation molecule (SLAM) family, also known as SLAMF2 and BLAST-1. It is constitutively expressed on most hematopoietic cells (not on neutrophils and a subset of long-term hematopoietic stem cells in mice) and can be upregulated under certain conditions like infection (1). Interaction with its low affinity ligand CD2 promotes adhesion and TCR signaling (2,3). Interaction with the high affinity ligand CD244 (2B4) regulates natural killer (NK) and CD8 T cell activation and cytolytic function (4-6).

Specifications