Cell Signaling Mhc Class I (Emr8-5) Mouse mAb (Bsa And Azide Free)

Name: Cell Signaling Mhc Class I (Emr8-5) Mouse mAb (Bsa And Azide Free)
SKU: CSIG-28149SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Mhc Class I (Emr8-5) Mouse mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-28149SF

MFG.PART: 28149SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	30-50
Source/Isotype	Mouse IgG1 kappa
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #88274
Specificity/Sensitivity	MHC Class I (EMR8-5) Mouse mAb (BSA and Azide Free) detects HLA-A, HLA-B, HLA-C, and HLA-E. This antibody does not cross-react with HLA-G.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with human HLA-A*2402 extracellular domain recombinant protein.
Background	The human leukocyte antigen (HLA) system is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans. These cell surface proteins are responsible for the regulation of antigen-specific immunity in humans. HLA genes are highly polymorphic, allowing them to fine-tune the adaptive immune response. HLAs corresponding to MHC class I (HLA-A, B, and C) present small peptide antigens from inside the cell, approximately 8 to 10 amino acids in length, to CD8+ T lymphocytes in order to activate a cytotoxic T cell response. HLAs corresponding to MHC class II (HLA-DP, DM, DO, DQ, and DR) present antigens from outside of the cell, approximately 15 to 24 residues in length, to CD4+ T helper cells, which in turn secrete cytokines and stimulate B cells to produce antibodies to that specific antigen. HLAs corresponding to MHC class III encode components of the complement system (1,2).

Specifications