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Cell Signaling Hoxb9 (E7p5o) Rabbit mAb
List Price
$342.39
Your Price
$342.39
Cell Signaling Hoxb9 (E7p5o) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-27967S
MFG.PART:
27967S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H Mk |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 28 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:100, Immunofluorescence (Immunocytochemistry): 1:400 - 1:1600, Flow Cytometry (Fixed/Permeabilized): 1:800 - 1:1600} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | HOXB9 (E7P5O) Rabbit mAb recognizes endogenous levels of total HOXB9 protein. This antibody does not cross-react with HOXA9, HOXC9, or HOXD9 proteins. |
| Species Reactivity | Human, Monkey |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val116 of human HOXB9 protein. |
| Background | HOXB9 is a member of the HOXB gene cluster which, along with the HOXA, HOXC, and HOXD gene clusters, governs embryonic patterning along the cranio-caudal axis (1,2). HOXB9 protein functions to regulate formation of the rib cage and contributes to development of the forelimbs (3,4). De-regulation of HOXB9 protein expression is associated with multiple types of cancer. HOXB9 expression is downregulated in pancreatic ductal adenocarcinoma and upregulated in lung adenocarcinoma, where it is associated with poor prognosis (5,6). Overexpression of HOXB9 in breast and hepatocellular carcinomas activates the epithelial-to-mesenchymal transition (EMT) through modulation of TGF-β, promoting tumor progression and metastasis (7,8). HOXB9 overexpression in gliomas increases tumorigenicity by stimulating proliferation, migration, and sphere formation (9). |
| SKU | CSIG-27967S |
|---|---|
| Featured | No |
| Supplier Part Number | 27967S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |