Cell Signaling Cul3 Antibody

Name: Cell Signaling Cul3 Antibody
SKU: CSIG-2759S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Cul3 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-2759S

MFG.PART: 2759S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	82, 84
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CUL3 Antibody detects endogenous levels of total Cullin-3.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu750 of human Cullin-3. Antibodies are purified by protein A and peptide affinity chromatography.
Background	CUL3 (Cullin-3) is a member of the cullin-based ubiquitin ligase family. By interacting with Hrt1 and BTB domain containing proteins, the complex functions as a CUL3-based E3 ligase to bring specific substrates to ubiquitinylation and degradation (1). The CUL3 complex has been shown to target many substrates involved in cell cycle progression (2), transcription (3), development and differentiation (4,5).

Specifications