Cell Signaling Spink3 Antibody

Name: Cell Signaling Spink3 Antibody
SKU: CSIG-2744S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Spink3 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-2744S

MFG.PART: 2744S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	M R
Sensitivity	Endogenous
Molecular Weight (kDa)	10
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	SPINK3 Antibody detects endogenous levels of total SPINK3 protein.
Species Reactivity	Mouse, Rat
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of the mouse SPINK3 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	The Kazal type 3 serine peptidase inhibitor (SPINK3) is a serine peptidase inhibitor expressed in the adult pancreas that protects acinar cells from trypsin-induced cell damage (1). Ingestion of milk by newborn SPINK3 knock out mice triggers autophagic cell death in pancreatic acinar cells and the complete disappearance of the pancreas (2). Mutations in the human SPINK3 homolog (known as SPINK1) are associated with chronic pancreatitis, presumably through decreased protection against trypsin-induced autophagic cell death (1,3). SPINK3 may be involved in the embryonic development of several other tissues (4).

Specifications