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Cell Signaling Cd11alpha (E5s9k) Rabbit mAb
List Price
$360.57
Your Price
$360.57
Cell Signaling Cd11alpha (E5s9k) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-26703S
MFG.PART:
26703S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 160 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50, Immunohistochemistry (Paraffin): 1:400 - 1:1600} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #36769. |
| Specificity/Sensitivity | CD11α (E5S9K) Rabbit mAb recognizes endogenous levels of total CD11α protein. |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val975 of human CD11α protein. |
| Background | CD11α, also known as integrin alpha-L (ITGAL), is the alpha chain of the lymphocyte function-associated antigen-1 (LFA-1). CD11α combines with the beta chain CD18 (ITGB2) to form LFA-1, an integrin expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAM-1, 2, 3, and 4 (1), F11R/JAM-1 (2,3), and the secreted form of ubiquitin-like protein ISG15 (4). LFA-1 is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction and transmigration (2,3), cytotoxic T cell co-stimulation (5), cytotoxic NK cell mediated killing (6), leukocyte clearance (7), and antibody-dependent killing by granulocytes and monocytes (8,9). LFA-1 is required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (10). High expression of CD11α has been associated with antigen-specific and tumor-reactive T cells (11,12). |
| SKU | CSIG-26703S |
|---|---|
| Featured | No |
| Supplier Part Number | 26703S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |