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Cell Signaling Ap4b1 Antibody
List Price
$309.06
Your Price
$309.06
Cell Signaling Ap4b1 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-26081S
MFG.PART:
26081S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 80 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | AP4B1 Antibody recognizes endogenous levels of total human AP4B1 protein. Weak reactivity has been observed in rodent. |
| Species Reactivity | Human |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile708 of human AP4B1 protein. Antibodies are purified by protein A and peptide affinity chromatography. |
| Background | AP (adaptor protein) complexes regulate intracellular membrane trafficking along endocytic and secretory pathways (1). There are five AP complexes (AP1-5) that exist as heterotetrameric complexes functioning at distinct intracellular compartments. The AP4 complex, which includes AP4E1, AP4B1, AP4M1, and AP4S1, functions at the trans-Golgi network (TGN) (2-4). AP-4 associates with Atg9A which is critical in autophagosome biogenesis (5). Deficiency in AP-4 led to Atg9A retention within the trans-Golgi network with defective axonal autophagosome generation (5). AP-4 deficiency has been linked to a group of neurodegenerative diseases known as hereditary spastic paraplegia. Mutation in the AP4B1 gene was identified as a cause for the neurological disorder hereditary spastic paraplegia type 47 (SPG47) (6,7). |
| SKU | CSIG-26081S |
|---|---|
| Featured | No |
| Supplier Part Number | 26081S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |