Cell Signaling Paxillin Antibody

Name: Cell Signaling Paxillin Antibody
SKU: CSIG-2542S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Paxillin Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-2542S

MFG.PART: 2542S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk B Pg
Sensitivity	Endogenous
Molecular Weight (kDa)	68
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Paxillin Antibody detects endogenous levels of total paxillin protein. The antibody does not cross-react with related proteins.
Species Reactivity	Human, Mouse, Rat, Monkey, Bovine, Pig
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy-terminus of human paxillin. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Paxillin is a multidomain protein that localizes primarily to focal adhesion sites in the extracellular matrix (1). Paxillin is one of the key components of integrin signaling, and tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization (2). Paxillin is phosphorylated by another focal adhesion component, focal adhesion kinase (FAK), at Tyr118 (3,4). Phospho-paxillin (Tyr118) may provide a docking site for recruitment of other signaling molecules to focal adhesions. It has been shown that the SH2 domain of Crk binds to the phosphorylated Tyr118 of paxillin (5).

Specifications