Cell Signaling Lair-1 (E7x6i) Xp® Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Lair-1 (E7x6i) Xp® Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-25289SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Lair-1 (E7x6i) Xp® Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-25289SF

MFG.PART: 25289SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	50
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #60061
Specificity/Sensitivity	LAIR-1 (E7X6I) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total LAIR-1 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human LAIR-1 protein.
Background	LAIR-1 is an inhibitory receptor that belongs to the Immunoglobulin superfamily. It has one extracellular Ig-like domain and an intracellular C-terminus with two ITIM (immunoreceptor tyrosine-based inhibitory motif) domains. It is found on peripheral mononuclear cells, including NK, T, and B cells, and is thought to play a negative regulatory role on the cytolytic function of these cells through signaling through collagen ligation (1). LAIR1 has been noted to be upregulated in renal cell carcinoma (2), and may play a role in expansion of Th17 cell populations in collagen-rich environments, such as in graft rejection tissue (3).

Specifications