Cell Signaling Cd163 (D6u1j) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Cd163 (D6u1j) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-25121SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Cd163 (D6u1j) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-25121SF

MFG.PART: 25121SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	160, 170
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #93498.
Specificity/Sensitivity	CD163 (D6U1J) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total CD163 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the human CD163 protein.
Background	CD163 is a transmembrane scavenger receptor expressed on the macrophage surface. It has 9 B-type Scavenger Receptor Cysteine-Rich (SRCR) extracellular domains mediating serum haptoglobin clearing/endocytosis, pathogen binding and signal transduction, and calcium binding (1,2). CD163 is used as a surface marker of M2 type macrophages, including M2 type tumor-associated macrophages (TAMs), which facilitate cancer progression by secreting cytokines to promote angiogenesis, immunosuppression, and metastasis (3). Inflammatory stimulation and stress signals can induce extracellular domain shedding of CD163 to generate soluble CD163 (sCD163). The increased sCD163 level in serum is associated with low-grade inflammation in disease conditions (4-7).

Specifications