Cell Signaling Oas2 (E2g4k) Rabbit mAb

Name: Cell Signaling Oas2 (E2g4k) Rabbit mAb
SKU: CSIG-24344S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Oas2 (E2g4k) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-24344S

MFG.PART: 24344S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	70
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	OAS2 (E2G4K) Rabbit mAb recognizes endogenous levels of total OAS2 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala330 of human OAS2 protein.
Background	2’-5’-oligoadenylate synthetase 2 (OAS2) is an enzyme induced by type 1 interferon that plays a key role in the host antiviral innate immune response (1,2). The OAS family of proteins includes OAS1, OAS2, OAS3, and OASL in humans (3). OAS2 is activated by cytosolic dsRNA and its enzymatic activity generates the second messenger 2’-5’-linked oligoadenylate. These 2’-5’-linked oligoadenylates bind to the ribonuclease RNase L, which then degrades viral and cellular RNA in an effort to curb viral replication (1). Research studies have shown that components of the OAS-RNase L system, including OAS2, are highly upregulated in response to SARS-CoV-2 infection, suggesting a role for this antiviral pathway in the pathogenesis of SARS-CoV-2 (4,5).

Specifications