Cell Signaling Gigyf2 Antibody

Name: Cell Signaling Gigyf2 Antibody
SKU: CSIG-24120S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Gigyf2 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-24120S

MFG.PART: 24120S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	180
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	GIGYF2 Antibody recognizes endogenous levels of total GIGYF2 protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu355 of human GIGYF2 protein. Antibodies are purified by peptide affinity chromatography.
Background	GRB10-interacting GYF protein 2 (GIGYF2) is part of a macromolecular protein complex, which also also contains 4EHP, that functions to repress the translation of a distinct subset of mRNAs during embryonic development. Indeed, disruption of 4EHP and GIGYF2 complex formation prevents normal embryonic development in mice (1). Research studies have also demonstrated that GIGYF2 is involved in repressing translation of defective mRNAs, which prevents expression of potentially toxic protein products (2). In addition to its role in repression of protein translation, GIGYF2 may cooperate with the Grb10 adapter protein to regulate signaling of receptor tyrosine kinases (3).

Specifications