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Cell Signaling Antxr1/Tem8 Antibody
List Price
$309.06
Your Price
$309.06
Cell Signaling Antxr1/Tem8 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-23494S
MFG.PART:
23494S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H M |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 80 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | ANTXR1/TEM8 Antibody recognizes endogenous levels of total ANTXR1/TEM8 protein. |
| Species Reactivity | Human, Mouse |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg557 of human ANTXR1/TEM8 protein. Antibodies are purified by peptide affinity chromatography. |
| Background | ANTXR1 (Anthrax toxin receptor 1, TEM8, tumor endothelial marker 8) is a protein biomarker induced in tumor-associated endothelia and acts as a cell surface receptor for the anthrax toxin and the oncolytic Seneca Valley Virus (1-3). The protein is a type I transmembrane glycoprotein that is expressed on the epithelial cell surface of skin, lung, and intestine tissues as a docking site for toxin/virus binding and endocytosis, and in tumor endothelial cells for tumor-associated vascular development (4). ANTXR1 interacts with type I and type VI collagens in the extracellular matrix, and with actin cytoskeleton in the cytoplasm to promote tumor-associated endothelial cell adhesion, migration, and spreading during angiogenesis (4-6). Aberrant high expression of ANTXR1 has been found in various cancer types including metastatic breast cancer cells, pancreatic cancer stem cells, etc. (7-9); there the protein promotes tumor proliferation, growth, and invasion. Because of its specific high expression in tumors and to their surrounding vasculature, ANTXR1 has been proposed as a target for CAR T cell therapy for cancer treatment (10,11). |
| SKU | CSIG-23494S |
|---|---|
| Featured | No |
| Supplier Part Number | 23494S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |