Cell Signaling Dynamin I/Ii Antibody

Name: Cell Signaling Dynamin I/Ii Antibody
SKU: CSIG-2342S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Dynamin I/Ii Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-2342S

MFG.PART: 2342S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	100
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:30}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Dynamin I/II Antibody detects endogenous levels of total dynamin protein. The antibody does not recognize the related dynamin-like protein DLP.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Tyr231 of human dynamin. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Dynamin is a family of large GTPases that has been implicated in the formation of vesicles of both the endocytotic and secretory processes (1). Dynamin plays an important role in the internalization of cell surface receptors, a process that attenuates the response to extracellular signals. It has been illustrated that dynamin interacts with signaling proteins such as Src, PLCγ, PKC and G-proteins. PKC and Src phosphorylate dynamin, and its phosphorylation may regulate the endocytosis of cell surface receptors (2,3).

Specifications