Cell Signaling Nup98 (L205) Antibody

Name: Cell Signaling Nup98 (L205) Antibody
SKU: CSIG-2288S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Nup98 (L205) Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-2288S

MFG.PART: 2288S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk B
Sensitivity	Endogenous
Molecular Weight (kDa)	98
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	NUP98 (L205) Antibody detects endogenous levels of NUP98 protein.
Species Reactivity	Human, Mouse, Rat, Monkey, Bovine
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu205 of human NUP98. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Nucleoporin 98 kDa (NUP98) is a component of the nuclear pore complex. It is expressed as three different precursors that undergo auto-cleavage to generate a common amino-terminal 98 kDa peptide (NUP98) and carboxy-terminal 6, 96 (NUP96) and 88 (p88) kDa peptides (1,2). NUP98 contains FG and GLFG repeat domains at its amino terminus and a RNA-binding domain in its carboxy terminus (3). The NUP98 gene is localized on chromosome 11p15.5, a region frequently rearranged in leukemias. To date, 15 fusion partners have been identified for NUP98 (4,5).

Specifications