Cell Signaling Mmp-9 (G657) Antibody

Name: Cell Signaling Mmp-9 (G657) Antibody
SKU: CSIG-2270S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Mmp-9 (G657) Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-2270S

MFG.PART: 2270S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	92
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	MMP-9 (G657) Antibody detects full length (proenzyme, 92 kDa) human MMP-9.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to a sequence based around amino acid residue Gly657 of human MMP-9. Antibodies are purified by protein A and peptide affinity chromatography.
Background	The matrix metalloproteinases (MMPs) are a family of proteases that target many extracellular proteins including other proteases, growth factors, cell surface receptors, and adhesion molecules (1). Among the family members, MMP-2, MMP-3, MMP-7, and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis, and apoptosis (2-4). Research studies have shown that MMP activity correlates with cancer development (2). One mechanism of MMP regulation is transcriptional (5). Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full-length protein (5).

Specifications