Cell Signaling Musashi Antibody

Name: Cell Signaling Musashi Antibody
SKU: CSIG-2154S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Musashi Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-2154S

MFG.PART: 2154S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	35
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Musashi Antibody detects endogenous levels of total Musashi 1 and 2 protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues of human Musashi. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Musashi-1 and Musashi-2 are RNA-binding proteins which play a role in asymmetric cell division of ectodermal precursor cells by regulating the translation of target mRNA. Both family members augment Notch signaling and repress the translation of m-Numb, a protein that positively modulates differentiation of neural stem cells into neurons. Thus, Musashi contributes to the maintenance of neural stem cells (1). While Musashi-1 is frequently used as a marker for proliferating neural precursor cells, it is also expressed in epithelial stem cells including intestinal and mammary gland stem cells (2-4).

Specifications