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Cell Signaling Sortilin Antibody
List Price
$309.06
Your Price
$309.06
Cell Signaling Sortilin Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-20681S
MFG.PART:
20681S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H M R |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 100 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | Sortilin Antibody recognizes endogenous levels of total sortilin protein. |
| Species Reactivity | Human, Mouse, Rat |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val361 of human sortilin protein. Antibodies are purified by peptide affinity chromatography. |
| Background | Sortilin is a multifunctional member of the vacuolar protein sortin-10 (VPS10) receptor family containing type-1 transmembrane proteins that have pleiotropic function in neuronal protein trafficking and viability (1). Sortilin is implicated to have inhibitory effects on tau aggregation in Alzheimers disease transgenic murine models expressing human mutated tau P301S (2), and also supports to regulate intracellular processing of amyloid precursor proteins (APP) (3,4) and β-secretase, which cleaves APP to produce neurotoxic Aβ peptides (5). Sortilin also plays a role in frontotemporal lobar degeneration (FTLD) by binding and regulating extracellular concentrations of the secreted glycoprotein progranulin (6). Sortilin has been linked to cholesterol circulating concentration and lifetime risk of developing significant atherosclerotic disease. Higher concentrations of sortilin have been found in patients with coronary atherosclerosis (7). Sortilin functions in the immune system within microglia, pro-inflammatory cytokine regulation, phagosome fusion, and pathogen clearance (8). |
| SKU | CSIG-20681S |
|---|---|
| Featured | No |
| Supplier Part Number | 20681S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |