Cell Signaling Ribosomal Protein L26 Antibody

Name: Cell Signaling Ribosomal Protein L26 Antibody
SKU: CSIG-2065S
Price: 317.14 USD

List Price $317.14 Your Price $317.14

Cell Signaling Ribosomal Protein L26 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-2065S

MFG.PART: 2065S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	17
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Ribosomal Protein L26 Antibody detects endogenous levels of total ribosomal protein L26.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human ribosomal protein L26. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Ribosomal protein L26 (RPL26) is a component of the 60S ribosomal subunit and is involved in translation (1,2). It was shown that RPL26 increases the translation of p53 mRNA by binding to its 5 untranslated region (UTR) after DNA damage. Studies found that overexpression of RPL26 enhances the binding of p53 mRNA to the ribosomes and increases p53 translation. Overexpression of RPL26 also induces cell-cycle arrest at G1 phase and increases radiation-stimulated apoptosis (2).

Specifications