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Cell Signaling Phospho-Tau (Ser46) Antibody
List Price
$360.57
Your Price
$360.57
Cell Signaling Phospho-Tau (Ser46) Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-20296S
MFG.PART:
20296S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H M R |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 50-80 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | Phospho-Tau (Ser46) Rabbit Antibody recognizes endogenous levels of Tau protein only when phosphorylated at Ser46. |
| Species Reactivity | Human, Mouse, Rat |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser46 of human Tau protein. Antibodies are purified by peptide affinity chromatography. |
| Background | Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by Erk, glycogen synthase kinase-3 (GSK-3), and CDK5 (1,2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimers disease (AD); these tangles are bundles of paired helical filaments (PHFs) composed of hyperphosphorylated tau. In particular, phosphorylation at Ser396 by GSK-3 or CDK5 destabilizes microtubules. Furthermore, research studies have shown that inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3).Phosphorylation of Tau at Ser46 is induced by different kinases, including GSK-3β (4), casein kinase-1 (5), and p38MAPK (6). Tau phosphorylation at Ser46 has been linked to different neurodegenerative diseases, including in PHF-Tau from Alzheimers disease (4,6), Progressive Supranuclear Palsy (7), and synucleinopathies (6). |
| SKU | CSIG-20296S |
|---|---|
| Featured | No |
| Supplier Part Number | 20296S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |