Cell Signaling Mmd (E4u4g) Rabbit mAb

Name: Cell Signaling Mmd (E4u4g) Rabbit mAb
SKU: CSIG-20226S
Price: 374.71 USD

List Price $374.71 Your Price $374.71

Cell Signaling Mmd (E4u4g) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-20226S

MFG.PART: 20226S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	22
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:200}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	MMD (E4U4G) Rabbit mAb recognizes endogenous levels of total MMD protein.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human MMD protein.
Background	MMD (monocyte to macrophage differentiation factor), also known as PAQR11, is a member of the PAQR (progestin and AdipoQ receptor) family that was identified in a screen based on differential expression in macrophages compared to monocyte progenitors (1). MMD/PAQR11 has seven transmembrane domains and is localized to the Golgi apparatus (2). It can form a complex with Ras and activate ERK signaling (2). Knockdown of MMD/PAQR11 inhibited monocyte differentiation and alleviated progression of collagen-induced rheumatoid arthritis (3). Expression of MMD/PAQR11 has been associated with epithelial-mesenchymal transition (EMT) and metastasis (4). Studies have also found that it can regulate starvation-mediated lipolysis in white adipose tissue and deletion of PAQR11 in mice leads to resistance in high-fat diet-induced obesity (5).

Specifications