Cell Signaling Cd86 (E5w6h) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Cd86 (E5w6h) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-20018SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Cd86 (E5w6h) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-20018SF

MFG.PART: 20018SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	M
Sensitivity	Endogenous
Molecular Weight (kDa)	60-85
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #19589.
Specificity/Sensitivity	CD86 (E5W6H) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total CD86 protein.
Species Reactivity	Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with mouse CD86 recombinant protein.
Background	CD80 (B7-1, BB1) and CD86 (B7-2, B70) are members of the B7 family of cell surface ligands that regulate T cell activation and immune responses. CD80 is expressed on activated antigen presenting cells, including dendritic cells, B cells, monocytes, and macrophages. CD86 is expressed on resting monocytes, dendritic cells, activated B lymphocytes, and can be further upregulated in the presence of inflammation (1-3). CD80 and CD86 are ligands for CD28, which functions as a T cell costimulatory receptor. Interaction of CD28 with CD80 or CD86 provides the second signal required for naïve T cell activation, T cell proliferation, and acquisition of effector functions (3-7). Alternatively, CD80 and CD86 also act as ligands to CTLA-4, which results in the downregulation of T cell activity (3,7-9).

Specifications