Cell Signaling B7-H4 (D1m8i) Xp® Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling B7-H4 (D1m8i) Xp® Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-17188SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling B7-H4 (D1m8i) Xp® Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-17188SF

MFG.PART: 17188SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	75
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #14572.
Specificity/Sensitivity	B7-H4 (D1M8I) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total B7-H4 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala141 of human B7-H4 protein.
Background	B7 homolog 4 (B7-H4, VTCN1) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses (1-3). B7-H4 protein contains two extracellular Ig-like V-type domains, a transmembrane domain, and a short, two amino acid intracellular domain (3). The B7-H4 protein is shown to inhibit T cell activation, proliferation, and cytokine production (1,4,5). Although B7-H4 mRNA is widely expressed, B7-H4 protein is restricted to antigen presenting cells and B cells (1). The B7-H4 protein is also found in several tumor types, including ovarian cancer and breast cancer (6). Research studies indicate that B7-H4 protein is present on the surface of ovarian tumor cells, and that targeted inhibition of B7-H4 using recombinant antibodies restores T cell activation pathways. These studies suggest some potential therapeutic value in blocking B7-H4 function and restoring T cell function in cancer patients (7,8).

Specifications