Cell Signaling Ace2 (Oti1d6) Mouse mAb

Name: Cell Signaling Ace2 (Oti1d6) Mouse mAb
SKU: CSIG-15983S
Price: 483.79 USD

List Price $483.79 Your Price $483.79

Cell Signaling Ace2 (Oti1d6) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-15983S

MFG.PART: 15983S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	120-135
Source/Isotype	Mouse IgG1
Application/Dilution	{Western Blotting: 1:2000}
Storage	Supplied in PBS (pH 7.3), 1% BSA, 0.02% sodium azide, and 50% glycerol. Stable for 12 months when stored at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	ACE2 (OTI1D6) Mouse mAb recognizes endogenous levels of ACE2 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein corresponding to amino acids 18-237 of human ACE2 protein.
Background	ACE2 is a carboxypeptidase that catalyses the conversion of angiotensin I to angiotensin 1-9, or of angiotensin II to the vasodilator angiotensin 1-7 (1). ACE2 is a critical component in the renin-angiotensin system (RAS). ACE2 is predominantly expressed in vascular endothelial cells of the heart and kidney and Leydig and Sertoli cells of the testis (2,3). The unique expression pattern of ACE2 determines its essential role in the regulation of cardiovascular and kidney functions, as well as fertility. ACE2 protein is localized mainly in the extracellular space with its carboxy terminal end attached to the membrane via its transmembrane domain. Active ACE2 enzyme is secreted by cleavage at the amino terminus. Research studies have shown that ACE2 expression is elevated in human failing heart (4). ACE2 has also been identified as the receptor for SARS and SARS-CoV-2 coronaviruses (5-7).

Specifications