Cell Signaling Cd34 (E2j1k) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Cd34 (E2j1k) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-15518SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Cd34 (E2j1k) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-15518SF

MFG.PART: 15518SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	M
Sensitivity	Endogenous
Molecular Weight (kDa)	80-120
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #26233
Specificity/Sensitivity	CD34 (E2J1K) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total CD34 protein. Nuclear background may be observed in cultured cell lines by immunofluorescence.
Species Reactivity	Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with mouse CD34 recombinant protein.
Background	CD34 is a type I transmembrane glycophosphoprotein expressed by hematopoietic stem/progenitor cells, vascular endothelium and some fibroblasts (1). CD34 expression has been the hallmark used to identify hematopoietic stem cells for many years. CD34+ hematopoietic stem cells expand and differentiate into all the lymphohematopoietic lineages upon cytokine or growth factor stimulation and lose CD34 expression upon differentiation. However, recent studies performed in various laboratories conflict with that convention (2). The extracellular domain of CD34 is homologous to CD43, a protein involved in cell-cell adhesion, and CD34 has been shown to function as a negative regulator of cell adhesion (3). CD34 associates with CrkL but not CrkII, is a substrate for PKC, and activation of PKC is coupled with surface expression of CD34 (1,4).

Specifications