Cell Signaling Cxcl10 (D5l5l) Rabbit mAb

Name: Cell Signaling Cxcl10 (D5l5l) Rabbit mAb
SKU: CSIG-14969S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Cxcl10 (D5l5l) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-14969S

MFG.PART: 14969S

UNSPSC: 41116124

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	10
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CXCL10 (D5L5L) Rabbit mAb recognizes endogenous levels of total CXCL10 protein. This antibody also cross-reacts with a 100kDa protein of unknown orgin in some cell lines.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to human CXCL10 protein.
Background	Chemokine (C-X-C motif) ligand 10 (CXCL10, IP-10) is a chemokine produced by a number of cell types and that is induced in response to pro-inflammatory cytokines, such as IFN-γ and TNF-α (1,2). CXCL10 binds to the chemokine receptor CXCR3 and induces calcium flux and cell migration (3). The CXCR3 protein is normally expressed on activated CD4+ T cells and NK cells, which can produce pro-inflammatory cytokines, including IFN-γ and TNF-α (3,4). As a result, these molecules act in an amplification loop to promote immune responses in the contexts of both autoimmunity and a tumor immune response (5,6).

Specifications