Cell Signaling Pld2 (E1y9l) Rabbit mAb (Ihc Specific)

Name: Cell Signaling Pld2 (E1y9l) Rabbit mAb (Ihc Specific)
SKU: CSIG-13891S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Pld2 (E1y9l) Rabbit mAb (Ihc Specific) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-13891S

MFG.PART: 13891S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	95
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunohistochemistry (Paraffin): 1:250}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	PLD2 (E1Y9L) Rabbit mAb recognizes endogenous levels of total PLD2 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala880 of human PLD2 protein.
Background	Phosphatidylcholine-specific phospholipase D (PLD) hydrolyzes phosphatidylcholine (PC) to produce choline and phosphatidic acid (PA). PA is the precursor of the second messenger, diacylglycerol (DAG). Two isoforms of PLD (PLD1 and PLD2) have been identified so far. Both are regulated by protein kinases, small GTPases and Ca2+ (1). The PLD2 isoform is highly expressed in many cancers, such as colorectal and breast cancers (2,3). PLD2 also acts as a guanine nucleotide exchange factor for the small GTPase Rac2 independent of its phospholipase activity (4).

Specifications