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Cell Signaling Mcur1 Antibody
List Price
$309.06
Your Price
$309.06
Cell Signaling Mcur1 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-13706S
MFG.PART:
13706S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H M R Mk |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 23 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | MCUR1 Antibody recognizes endogenous levels of total MCUR1 protein. |
| Species Reactivity | Human, Mouse, Rat, Monkey |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala305 of human MCUR1 protein. Antibodies are purified by protein A and peptide affinity chromatography. |
| Background | Mitochondrial Calcium Uniporter Regulator 1 (MCUR1) is a mitochondrial inner membrane protein involved in the uptake of calcium. This multi-pass protein contains two transmembrane domains with both amino- and carboxy-termini projecting into the same mitochondrial intermembrane space (1). Research studies indicate that reduction in MCUR1 activity results in decreased mitochondrial Ca2+ uptake, while overexpression of MCUR1 results in increased mitochondrial calcium levels (1). MCUR1 protein directly interacts with mitochondrial calcium uniporter (MCU) and plays an essential role in the regulation of calcium uptake and maintenance of mitochondrial calcium homeostasis (1). Regulation of MCU by MCUR1 may be critical for a variety of cellular functions, including signal transduction, bioenergetics, and cell death and survival (2). |
| SKU | CSIG-13706S |
|---|---|
| Featured | No |
| Supplier Part Number | 13706S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |