Cell Signaling Lmx1b (D1e2) Rabbit mAb

Name: Cell Signaling Lmx1b (D1e2) Rabbit mAb
SKU: CSIG-13457S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Lmx1b (D1e2) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-13457S

MFG.PART: 13457S

UNSPSC: 41116111

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Transfected Only
Molecular Weight (kDa)	50
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Lmx1B (D1E2) Rabbit mAb recognizes transfected levels of total Lmx1B protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Lmx1B protein.
Background	LIM homeobox transcription factor 1 β (Lmx1B) is a member of an evolutionarily conserved family of transcription factors that regulate developmental pattern formation in both vertebrates and invertebrates (1). Numerous developmental studies show that Lmx1B is required for vertebrate dorsoventral limb patterning, as well as normal glomerular basement membrane development and typical differentiation of central serotonergic neurons (2,3).Mutations in the corresponding Lmx1B gene have been associated with nail-patella syndrome (NPS), an autosomal dominant disorder characterized by dysplasia of fingernails, skeletal anomalies and, frequently, renal disease (2). Abnormal developmental disorders such as developmental glaucoma and idiopathic Parkinson’s disease have also been associated with Lmx1B function (4,5).

Specifications