Cell Signaling Kinectin 1 (D5f7j) Rabbit mAb

Name: Cell Signaling Kinectin 1 (D5f7j) Rabbit mAb
SKU: CSIG-13243S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Kinectin 1 (D5f7j) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-13243S

MFG.PART: 13243S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H Mk Dg
Sensitivity	Endogenous
Molecular Weight (kDa)	160
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:100, Immunofluorescence (Immunocytochemistry): 1:100}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Kinectin 1 (D5F7J) Rabbit mAb recognizes endogenous levels of total kinectin 1 protein.
Species Reactivity	Human, Monkey, Dog
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val186 of human kinectin 1 protein.
Background	Kinectin 1 (KTN1) is an endoplasmic reticulum (ER)-enriched integral membrane protein that may be involved in the formation of ER sheets (reviewed in 1). Kinectin 1 binds the microtubule motor protein kinesin and acts as a membrane anchor for kinesin-based organelle trafficking (2). The interaction of kinesin with kinectin 1 has been shown to affect ER-supported focal adhesion assembly (3). Kinectin 1 has also been implicated in translation elongation, as an anchor for the elongation factor complex to the ER (4,5). Research investigators have shown that kinectin 1 expression is altered in multiple human pathologies, including breast cancer (6), hepatocellular carcinoma (HCC) (7), Parkinsons disease (8), and the autoimmune syndrome Behçets disease (BD) (9,10).

Specifications