Cell Signaling Vamp1 Antibody

Name: Cell Signaling Vamp1 Antibody
SKU: CSIG-13151S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Vamp1 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-13151S

MFG.PART: 13151S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	16
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	VAMP1 Antibody recognizes endogenous levels of total VAMP1 protein. This antibody does not cross-react with VAMP2.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human VAMP1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Vesicle-associated membrane protein 1 (VAMP1), also called synaptobrevin 1, is part of the R-soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex (1). The SNARE complex is involved in calcium regulated vesicular transport and membrane fusion (2). While related protein VAMP2 exhibits a wider distribution and is more abundant in the brain, VAMP1 is the main isoform in specific brain regions including the subthalamus nucleus zona incerta (1), the ostral periolivary region, and the retina (3). In addition, VAMP1 is involved in neurotransmitter release at the neuromuscular junction (4) and in the release of bioactive peptides from cardiac myocytes (5).

Specifications