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Cell Signaling Tal1 Antibody
List Price
$309.06
Your Price
$309.06
Cell Signaling Tal1 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-12831S
MFG.PART:
12831S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Transfected Only |
| Molecular Weight (kDa) | 50 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | TAL1 Antibody recognizes transfected levels of total TAL1 protein. |
| Species Reactivity | Human |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human TAL1 protein. Antibodies are purified by protein A and peptide affinity chromatography. |
| Background | The basic helix-loop-helix (bHLH) family of transcription factors play roles in a variety of developmental and adult biological settings (1). The basic (b) domain of bHLH transcription factors allows association with DNA, while the HLH domain facilitates the mono- and heterodimeric interactions required for efficient DNA binding (1). TAL1, also known as SCL, is a bHLH transcription factor that plays an essential role in the generation of embryonic hematopoietic stem cells (2), and is required for maturation of erythroid and megakaryocytic lineages in the adult (3). TAL1 interacts with Lim-domain containing proteins LMO2 and Ldb1, and has been found in complexes with these proteins as well as the hematopoietic transcription factor GATA-1 (4). Both TAL1 and LMO2 have been associated with T-cell acute lymphoblastic leukemia (T-ALL) (5,6). TAL1 activity is essential for both hematopoiesis and neurogenesis (7). |
| SKU | CSIG-12831S |
|---|---|
| Featured | No |
| Supplier Part Number | 12831S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |